Drifting between the states of alive and dead is against all the laws of nature but it's something Anti-life enables and revels in. Though there are many versions of the walking dead, the most threatening to humanity was one that was never intended to imbue unlife. It has been called many things but its official designation was the T-Serum.
The origins of the T-Serum lie with the Progenitor Compound which was discovered by doctors Oswell Spencer, James Marcus, and Edward Ashford. It's unclear where they got the compound from, but there are many rumors that they came from tainted fauna or microbiological life underground. The goal was to develop life-saving medical compounds, but soon they saw a far more lucrative venture.The Umbrella Group was a collection of companies founded by Markus, Spencer, and Ashford which worked to create the B-Serum, an alternative to the more renowned Super Soldier Serum. Recipients were unstoppable, healing damage within seconds and regrowing lost limbs within minutes. They were, however, prone to fits of mindless rage, which limited their application on the battlefield.
Things were progressing well until disaster struck. At a research facility somewhere in Raccoon Township, Illinois, a sample of the T-Serum was released. This version of the Compound was designed to be aerosolized in order to enhance large groups of soldiers but turned out to be highly toxic. However, even the researchers didn't realize that the compound still had regenerative properties and soon those the serum killed were walking again.
These Zombies were mindless creations instilled with boundless aggression. Following some perverse facsimile of biological function, they sought to consume the flesh of anyone that crossed their path. Even worse, their saliva contained enough T-Serum that anyone bitten would die and also rise as a zombie.
With hundreds of people infected with the T-Serum, it took a clandestine effort by the Office of National Emergency, Covert Action Team Shield, and elements of United States Special Forces to stop the spread. Afterward, intelligence agencies started to discover the horrifying experiments undertaken by Umbrella and by noted doctor Albert Wesker in particular.
The Umbrella Group was shut down but Dr. Wesker escaped. Since that time, the rogue doctor has attempted to revive the T-Serum program, only to be stopped by an array of heroes. One such action by Rip Hunter created an alternate timeline where the Serum turned the world's heroes into zombies and ended civilization.